Myocardial Opiate Receptors
نویسندگان
چکیده
The effect of morphine and niet-enkephaline on the isometric contraction of rabbit papillary muscles was studied. The tested compounds produced a dose-dependent, stereospecific and naloxon-reversible negative inotropic effect indicating the existence of opiate receptors in cardiac muscle. A pretreatment of papillary muscles with the /3-blocking agent atenolol attenuated the negative inotropic action of morphine and met-enkephaline suggesting a presynaptic localization of cardiac opiate receptors.
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تاریخ انتشار 2010